← Claim Coverage Screen
US 12,377,100 B2 — Gilead Sciences, Inc.
Gilead TLR8 modulator genus -- joint-constraint hub position
This genus includes a real claim-drafting pattern our engine specifically handles: three separately-labeled positions (R11, R12, R13) sharing one drawn hub atom, varying only together as whole pre-drawn alternative fragments -- not independently, the way most Markush positions do.
MEMBERClC1=C(C)C2=NC(N)=NC(NCCCC(C)CO)=C2N=C1
R-group position analysis
R1Matched
Claim-allowed values: hydrogen (hydrogen also allowed)
Target has: hydrogen
R2Matched
Claim-allowed values: hydrogen, methyl, fluoro, chloro (hydrogen also allowed)
Target has: chloro
R3Matched
Claim-allowed values: hydrogen, methyl (hydrogen also allowed)
Target has: methyl
R11/R12/R13 (merged hub)Matched
Claim-allowed values: CCCCC(C)CO, CCCC(C)CO, CCCCC[C](C)CO, CCCC[C](C)C(C)O, CCCC[C](C)[C@H](C)O
Target has: CCCC(C)CO
Reasoning
- R1: no substituent found at this position (target has plain hydrogen here), and hydrogen is an allowed value -- OK
- R2: substituent 'Cl' matches an explicitly allowed value (hydrogen, methyl, fluoro or chloro) -- OK
- R3: substituent 'C' matches an explicitly allowed value (hydrogen or methyl) -- OK
- R11/R12/R13: substituent 'CCCC(C)CO' matches an explicitly allowed drawn-alternative value for this jointly-varying hub position -- OK