Diclofenac: nitrosamine formation-potential index 40/100 (moderate), 2 structural alerts, 0 predicted degradants

Impurity & Nitrosamine Risk screen of Diclofenac (structure from PubChem CID 3033). The engine finds 1 nitrosation site(s) and predicts these N-nitroso structures: N-nitroso-diclofenac. Structural alerts: 2. Predicted degradants under stress conditions: 0. Computational screen of the public structure. Not a regulatory determination, not a finding about any manufacturer's product, no acceptable intakes or CPCA categories assigned.

How the engine decided

Run a nitrite-spiked forced-degradation study (drug substance and, if relevant, the formulated product) and develop a nitrosamine-specific method (LC-MS/MS with a nitrosamine reference standard).
Audit the route and the excipient/solvent list for nitrosating agents (nitrite salts, nitrous acid, nitro solvents, amines, recycled solvents, water sources).

Confidence: auto-verified: this result did not require human review before publishing.

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