Tofacitinib: nitrosamine formation-potential index 0/100 (no nitrosation site found), 1 structural alerts, 4 predicted degradants

Impurity & Nitrosamine Risk screen of Tofacitinib (structure from PubChem CID 9926791). The engine finds 0 nitrosation site(s). Structural alerts: 1. Predicted degradants under stress conditions: 4, 2 introducing a new liability. Computational screen of the public structure. Not a regulatory determination, not a finding about any manufacturer's product, no acceptable intakes or CPCA categories assigned.

How the engine decided

Prioritise stress studies that generate the degradants carrying new alerts and assess those degradants for specification and ICH M7 purposes.

Confidence: auto-verified: this result did not require human review before publishing.

What we do

Need this run on your own compound?

This is one of many patents we screen daily. If you have a specific compound or patent you need checked, we'll run a free sample report on it.