Genus/Species (Markush) Claim Coverage Analysis
Does a specific compound fall inside a patent's broad genus claim?
Need this run on your own compound or patent? Markush Coverage needs a hand-reviewed case build, not an automated minutes-long check: get a Standard Report with real human sign-off.
Dapagliflozin (PubChem CID 9887712): MEMBER against US6414126B1's Markush genus claim
RDKit R-group decomposition tested Dapagliflozin (PubChem CID 9887712)'s real structure against US6414126B1's claim 1 Markush formula: MEMBER. Real case: AstraZeneca v. Torrent/MSN/USV/Zydus/Eris/Micro Labs, Delhi HC, 2020-11-18 (AstraZeneca denied injunctions against generics for dapagliflozin, IN205147 genus vs. IN205625 species).
Ceritinib (PubChem CID 57379345): MEMBER against US8039479B2's Markush genus claim
RDKit R-group decomposition tested Ceritinib (PubChem CID 57379345)'s real structure against US8039479B2's claim 1 Markush formula: MEMBER. Real case: Novartis AG & Anr. v. Natco Pharma Limited, Delhi HC, injunction granted 2023-01-09 (IN276026, claim 1 Markush genus + claim 4 ceritinib + Example 7 synthesis, all in the same patent).
Risdiplam (PubChem CID 118513932): MEMBER against US9586955B2's Markush genus claim
RDKit R-group decomposition tested Risdiplam (PubChem CID 118513932)'s real structure against US9586955B2's claim 1 Markush formula: MEMBER. Real case: F. Hoffmann-La Roche AG v. Natco Pharma Limited -- Delhi HC Division Bench affirmed refusal of interim injunction, 2025-10-10 (case remains active, further appeal possible). IMPORTANT: this structural-coverage result answers a narrower question than the one actually being litigated (whether the genus DISCLOSES/ENABLES risdiplam specifically, an inventive-step/validity question -- Roche's own position is that coverage is not disputed). This result does not predict, endorse, or prejudge that active dispute's outcome.
Frequently asked
What does Markush/genus coverage analysis check?
Whether a specific compound structurally falls inside a patent's broad genus (Markush) claim, using real cheminformatics substructure matching rather than a keyword search.
How is this delivered?
A free automated instant check is available (patent number + your compound) via the Newest Patent Extraction tool's Markush mode: it parses the genus diagram and claim text automatically and confirms a match when it can. When it can't confirm automatically, you get the free result plus the option to escalate to a human-reviewed Standard Report ($199).
Can I see a real example first?
Yes: real, currently-live sample results are listed on this page for free before you request anything.