For the study of reaction mechanism in organic chemistry isotopic labeling, e. g. with 2 H or 17 O c — Organic Chemistry Chemistry Question
Atom Mobility (Dynamics ) in Organic Compounds
For the study of reaction mechanism in organic chemistry isotopic labeling, e. g. with 2 H or 17 O can give valuable information. Modern NMR techniques are able to “see“ deuterium 2 H and the oxygen isotope 17 O. As an example, the introduction of isotopic labels in 4-hydroxybutan-2-one is considered.
a, b, c, d are hydrogen atoms, x, y are oxygen atoms and m is a carbon atom.
The substrate is treated with 2 H2O at pH = 10. Rank the order the exchange (introduction) of deuterium atoms ( 2 H) from first to last.
First last.
Model Answer
a >> c, d > b
Similarly the substrate is treated with H2 17 O at pH = 10. Rank the order of introduction of 17 O from the first to the last.
First last.
Model Answer
y > x
Do you consider the exchange method appropriate for the introduction of a 13 C at position m. Yes or No?
Model Answer
No