Carboxy-functionalized fluorescein dyes, which have been employed as important conjugated fluorescen — Analytical Chemistry Chemistry Question
Synthesis of Building Blocks for Fluorescent Markers
Carboxy-functionalized fluorescein dyes, which have been employed as important conjugated fluorescent markers of biologically active compounds, can be synthesized based on the improved synthetic route developed by M.H. Lyttle and co-workers (Lyttle, M. H.; Carter, T. G.; and Cook, R. M. Org. Proc. Res. Dev. 2001, 5, 45 – 49). In these synthetic sequences, two different precursors (C and I) were required and they were synthesized as followed.
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28.1.
Identify compounds A-I.
Model Answer
Compounds A-I are shown below:
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