Testosterone is a hormone, which is a biologically active substance that has signaling properties, a — Physical Chemistry — Kinetics Chemistry Question
Formal synthesis of testosterone
Testosterone is a hormone, which is a biologically active substance that has signaling properties, and is produced in a living organism. It is observed in most vertebrates, both in female and male organism. Its effects on health are so important that [VISUAL]
[VISUAL] [Question text not fully present in source, yes/no query about testosterone or reaction feasibility]
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Yes.
[VISUAL] [Question text not fully present in source, query about reaction conditions or products after quenching]
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After quenching of the reaction: [VISUAL]
[VISUAL] [Question text not fully present in source, query regarding intermediate structures in synthesis step]
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[VISUAL]
[VISUAL] [Question text not fully present in source, query regarding intermediate structures in synthesis step]
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See question 3. [VISUAL]
[VISUAL] [Question text not fully present in source, query regarding the difference in reactivity between B and B']
Model Answer
B reacts because the reaction involving B’ would lead to a too stretched transition state for the reaction to occur.
[VISUAL] Draw the structure of D.
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[VISUAL] Circle the most acidic protons of D.
Model Answer
The protons in α position from a C=O double bond are more acidic than the others.
[VISUAL] In a mixture of KOH in MeOH, D yields two products. E is the thermodynamic product and E’ the kinetic one. E has three 6-membered rings and one 5-membered ring, while E’ has two 6- membered rings and two 5-membered rings. Draw the structure of these two products.
Model Answer
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